| | Statistic | FOR | OPP |
| Total Yards per Game | 435.0 | 419.5 |
| Rushing YDS per ATT | 5.3 | 4.5 |
| Passing YDS per ATT | 7.2 | 7.6 |
| Passing Comp % | 0.765 | 0.692 |
| Total YDS per Play | 6.5 | 6.8 |
| Total YDS per Point | 17.8 | 17.5 |
|
| Injury |
| [LB] 09/25/2021 - Keanu Neal is OUT Monday vs Philadelphia ( COVID-19 ) |
| [S] 09/25/2021 - Donovan Wilson is doubtful Monday vs Philadelphia ( Groin ) |
| [WR] 09/24/2021 - Amari Cooper is upgraded to probable Monday vs Philadelphia ( Ribs ) |
| [DE] 09/24/2021 - Bradlee Anae is OUT Monday vs Philadelphia ( COVID-19 ) |
| [DT] 09/24/2021 - Trysten Hill is OUT Monday vs Philadelphia ( Knee ) |
| [DE] 09/23/2021 - Dorance Armstrong Jr. is OUT Monday vs Philadelphia ( Ankle ) |
| [DE] 09/23/2021 - Carlos Watkins is OUT Monday vs Philadelphia ( Knee ) |
| [T] 09/23/2021 - Ty Nsekhe is OUT Monday vs Philadelphia ( Illness ) |
| [DE] 09/22/2021 - Randy Gregory is upgraded to probable Monday vs Philadelphia ( Quarantine ) |
| [DE] 09/15/2021 - Demarcus Lawrence IR ( Foot ) |
| [WR] 09/13/2021 - Michael Gallup IR ( Calf ) |
| [T] 09/10/2021 - La'el Collins is suspended 5 games (eligible to return 10/31 vs MIN) ( Suspension ) |
| [DT] 09/06/2021 - Neville Gallimore IR ( Elbow ) |
| [T] 09/06/2021 - Josh Ball IR ( Ankle ) |
| [CB] 09/06/2021 - Kelvin Joseph IR ( Groin ) |
| [WR] 09/06/2021 - Malik Turner IR ( Foot ) |
| [P] 09/06/2021 - Hunter Niswander IR ( Back ) |
| [LB] 09/06/2021 - Francis Bernard IR ( Hamstring ) |
| [T] 09/06/2021 - Mitch Hyatt IR ( Knee ) |
| [TE] 09/06/2021 - Sean McKeon IR ( Ankle ) |
| [FB] 09/06/2021 - Sewo Olonilua IR ( Neck ) |
| [CB] 09/06/2021 - Reginald Robinson II IR ( Toe ) |
| [RB] 08/25/2021 - Rico Dowdle IR ( Hip ) |
