| | Statistic | FOR | OPP |
| Total Yards per Game | 390.3 | 191.0 |
| Rushing YDS per ATT | 3.4 | 2.6 |
| Passing YDS per ATT | 8.0 | 5.0 |
| Passing Comp % | 0.682 | 0.575 |
| Total YDS per Play | 5.9 | 4.2 |
| Total YDS per Point | 17.0 | 19.1 |
|
| Injury |
| (!)[RB] 09/24/2021 - Christian McCaffrey is downgraded to OUT Sunday vs Dallas ( Hamstring ) |
| [G] 09/24/2021 - John Miller injured last game, is "?" Sunday vs Dallas ( Shoulder ) |
| [S] 09/24/2021 - Juston Burris left last game, is "?" Sunday vs Dallas ( Groin ) |
| [CB] 09/23/2021 - Jaycee Horn is out indefinitely ( Foot ) |
| [WR] 09/23/2021 - Shi Smith is "?" Sunday vs Dallas ( Shoulder ) |
| [DE] 09/22/2021 - Yetur Gross-Matos is "?" Sunday vs Dallas ( Ankle ) |
| [OL] 09/21/2021 - Pat Elflein IR ( Hamstring ) |
| [DB] 09/13/2021 - Myles Hartsfield IR ( Wrist ) |
| [CB] 09/06/2021 - Troy Pride Jr. IR ( Knee ) |
| [T] 09/06/2021 - Matt Kaskey IR ( Foot ) |
| [RB] 09/06/2021 - Darius Clark IR ( Knee ) |
| [LS] 09/06/2021 - Thomas Fletcher IR ( Hip ) |
| [DT] 09/06/2021 - Mike Panasiuk IR ( Undisclosed ) |
