| | Statistic | FOR | OPP |
| Total Yards per Game | 345.0 | 376.0 |
| Rushing YDS per ATT | 4.0 | 4.3 |
| Passing YDS per ATT | 6.3 | 9.6 |
| Passing Comp % | 0.635 | 0.698 |
| Total YDS per Play | 5.3 | 6.9 |
| Total YDS per Point | 17.3 | 13.7 |
|
| Injury |
| (!)[QB] 09/26/2021 - Carson Wentz is upgraded to probable Sunday vs Tennessee ( Ankle ) |
| [G] 09/24/2021 - Braden Smith is OUT Sunday vs Tennessee ( Foot ) |
| [CB] 09/24/2021 - Xavier Rhodes is probable Sunday vs Tennessee ( Calf ) |
| [WR] 09/24/2021 - Parris Campbell is probable Sunday vs Tennessee ( Abdominal ) |
| [LB] 09/24/2021 - Jordan Glasgow is OUT Sunday vs Tennessee ( Concussion ) |
| [WR] 09/06/2021 - Dezmon Patmon IR ( Foot ) |
| [T] 09/06/2021 - Sam Tevi IR ( ACL ) |
| [WR] 09/06/2021 - Quartney Davis IR ( Shoulder ) |
| [WR] 09/06/2021 - J.J. Nelson IR ( Groin ) |
| [S] 09/06/2021 - Nick Nelson IR ( Undisclosed ) |
| [TE] 09/06/2021 - Jordan Thomas IR ( Undisclosed ) |
| [LB] 09/06/2021 - Skai Moore IR ( Back ) |
| [DT] 09/06/2021 - Robert Windsor IR ( Undisclosed ) |
| [WR] 08/29/2021 - T.Y. Hilton IR ( Neck ) |
| [QB] 08/28/2021 - Sam Ehlinger IR ( Knee ) |
