| | Statistic | FOR | OPP |
| Total Yards per Game | 374.0 | 379.0 |
| Rushing YDS per ATT | 3.8 | 5.0 |
| Passing YDS per ATT | 8.9 | 6.1 |
| Passing Comp % | 0.714 | 0.617 |
| Total YDS per Play | 6.1 | 5.7 |
| Total YDS per Point | 12.9 | 17.2 |
|
| Injury |
| [RB] 09/21/2021 - Elijah Mitchell is probable Sunday vs Green Bay ( Shoulder ) |
| [DT] 09/20/2021 - Kevin Givens is out indefinitely ( Ankle ) |
| [CB] 09/20/2021 - Josh Norman injured last game, is "?" Sunday vs Green Bay ( Ankle ) |
| [RB] 09/20/2021 - JaMycal Hasty is out indefinitely ( Ankle ) |
| [RB] 09/19/2021 - Trey Sermon injured last game, is "?" Sunday vs Green Bay ( Concussion ) |
| [CB] 09/19/2021 - Emmanuel Moseley is "?" Sunday vs Green Bay ( Knee ) |
| [LB] 09/16/2021 - Dre Greenlaw IR ( Groin ) |
| [RB] 09/14/2021 - Raheem Mostert is out for season ( Knee ) |
| [CB] 09/13/2021 - Jason Verrett is out for season ( ACL ) |
| [WR] 09/11/2021 - Jalen Hurd IR ( Knee ) |
| [WR] 09/06/2021 - Richie James IR ( Knee ) |
| [DL] 09/06/2021 - Maurice Hurst IR ( Ankle ) |
| [T] 09/06/2021 - Justin Skule IR ( Knee ) |
