| | Statistic | FOR | OPP |
| Total Yards per Game | 291.5 | 398.0 |
| Rushing YDS per ATT | 3.3 | 3.4 |
| Passing YDS per ATT | 6.5 | 7.1 |
| Passing Comp % | 0.625 | 0.659 |
| Total YDS per Play | 5.4 | 5.8 |
| Total YDS per Point | 14.6 | 19.0 |
|
| Injury |
| [DT] 09/21/2021 - Tyson Alualu IR ( Ankle ) |
| (!)[QB] 09/21/2021 - Ben Roethlisberger is probable Sunday vs Cincinnati ( Pectoral ) |
| [LB] 09/21/2021 - Alex Highsmith is "?" Sunday vs Cincinnati ( Groin ) |
| [WR] 09/19/2021 - Diontae Johnson injured last game, is "?" Sunday vs Cincinnati ( Knee ) |
| [CB] 09/19/2021 - Joe Haden is "?" Sunday vs Cincinnati ( Groin ) |
| [LB] 09/19/2021 - Devin Bush is "?" Sunday vs Cincinnati ( Groin ) |
| [DT] 09/19/2021 - Carlos Davis is "?" Sunday vs Cincinnati ( Knee ) |
| [LB] 09/19/2021 - T.J. Watt left last game, is "?" Sunday vs Cincinnati ( Groin ) |
| [CB] 09/06/2021 - DeMarkus Acy IR ( Knee ) |
| [DT] 09/06/2021 - Demarcus Christmas IR ( Undisclosed ) |
| [QB] 09/06/2021 - Joshua Dobbs IR ( Toe ) |
| [DE] 09/06/2021 - Stephon Tuitt IR ( Knee ) |
| [T] 09/06/2021 - Zach Banner IR ( Knee ) |
| [RB] 09/02/2021 - Anthony McFarland Jr. IR ( Undisclosed ) |
