| | Statistic | FOR | OPP |
| Total Yards per Game | 314.7 | 385.7 |
| Rushing YDS per ATT | 3.3 | 4.2 |
| Passing YDS per ATT | 7.3 | 7.6 |
| Passing Comp % | 0.644 | 0.660 |
| Total YDS per Play | 5.4 | 6.1 |
| Total YDS per Point | 14.1 | 15.2 |
|
| Injury |
| [LB] 09/23/2021 - Kamu Grugier-Hill is "?" Sunday vs Buffalo ( Knee ) |
| [S] 09/23/2021 - Justin Reid is "?" Sunday vs Buffalo ( Knee ) |
| [CB] 09/22/2021 - Terrance Mitchell is "?" Sunday vs Buffalo ( Concussion ) |
| (!)[QB] 09/21/2021 - Tyrod Taylor IR ( Hamstring ) |
| [WR] 09/21/2021 - Nico Collins IR ( Shoulder ) |
| [WR] 09/21/2021 - Danny Amendola is out indefinitely ( Thigh ) |
| [DT] 09/16/2021 - Vincent Taylor IR ( Ankle ) |
| [LB] 09/16/2021 - Kevin Pierre-Louis IR ( Hamstring ) |
| [K] 09/09/2021 - Ka'imi Fairbairn IR ( Leg ) |
| [S] 09/06/2021 - A.J. Moore IR ( Hamstring ) |
| [CB] 09/06/2021 - Cornell Armstrong IR ( Undisclosed ) |
| [LB] 09/06/2021 - Tae Davis IR ( Undisclosed ) |
| (!)[QB] 05/12/2021 - Deshaun Watson is out indefinitely ( Legal problems ) |
