| | Statistic | FOR | OPP |
| Total Yards per Game | 406.0 | 349.5 |
| Rushing YDS per ATT | 5.2 | 3.0 |
| Passing YDS per ATT | 10.3 | 8.4 |
| Passing Comp % | 0.816 | 0.692 |
| Total YDS per Play | 7.4 | 6.0 |
| Total YDS per Point | 13.5 | 12.9 |
|
| Injury |
| [OL] 09/24/2021 - Chris Hubbard is OUT Sunday vs Chicago ( Triceps ) |
| [WR] 09/24/2021 - Odell Beckham Jr. is probable Sunday vs Chicago ( Knee ) |
| [LB] 09/24/2021 - Sione Takitaki is OUT Sunday vs Chicago ( Hamstring ) |
| [OL] 09/24/2021 - JC Tretter is "?" Sunday vs Chicago ( Undisclosed ) |
| [RB] 09/24/2021 - Demetric Felton is probable Sunday vs Chicago ( Hip ) |
| [LB] 09/24/2021 - Tony Fields II is probable Sunday vs Chicago ( Illness ) |
| [WR] 09/21/2021 - Jarvis Landry IR ( Knee ) |
| [T] 09/19/2021 - Jedrick Wills Jr. is "?" Sunday vs Chicago ( Ankle ) |
| [LB] 09/17/2021 - Anthony Walker IR ( Hamstring ) |
| [LB] 09/06/2021 - Jacob Phillips IR ( Biceps ) |
| [LB] 09/06/2021 - Montrel Meander IR ( Achilles ) |
| [TE] 09/06/2021 - Connor Davis IR ( Shoulder ) |
| [RB] 09/06/2021 - Tre Harbison IR ( Concussion ) |
| [WR] 09/06/2021 - Ryan Switzer IR ( Foot ) |
| [T] 09/06/2021 - Drew Forbes IR ( Knee ) |
| [TE] 09/06/2021 - Stephen Carlson IR ( Knee ) |
