| | Statistic | FOR | OPP |
| Total Yards per Game | 382.0 | 190.0 |
| Rushing YDS per ATT | 3.3 | 2.7 |
| Passing YDS per ATT | 7.7 | 4.9 |
| Passing Comp % | 0.685 | 0.525 |
| Total YDS per Play | 5.7 | 4.1 |
| Total YDS per Point | 17.0 | 18.1 |
|
| Injury |
| [OL] 09/21/2021 - Pat Elflein IR ( Hamstring ) |
| (!)[RB] 09/21/2021 - Christian McCaffrey is probable Thursday vs Houston ( Calf ) |
| [DE] 09/20/2021 - Yetur Gross-Matos is "?" Thursday vs Houston ( Ankle ) |
| [WR] 09/19/2021 - Shi Smith is "?" Thursday vs Houston ( Shoulder ) |
| [DB] 09/13/2021 - Myles Hartsfield IR ( Wrist ) |
| [CB] 09/06/2021 - Troy Pride Jr. IR ( Knee ) |
| [T] 09/06/2021 - Matt Kaskey IR ( Foot ) |
| [RB] 09/06/2021 - Darius Clark IR ( Knee ) |
| [LS] 09/06/2021 - Thomas Fletcher IR ( Hip ) |
| [DT] 09/06/2021 - Mike Panasiuk IR ( Undisclosed ) |
