| | Statistic | FOR | OPP |
| Total Yards per Game | 387.0 | 382.5 |
| Rushing YDS per ATT | 5.2 | 3.8 |
| Passing YDS per ATT | 5.9 | 10.2 |
| Passing Comp % | 0.688 | 0.755 |
| Total YDS per Play | 5.7 | 6.8 |
| Total YDS per Point | 15.5 | 10.1 |
|
| Injury |
| [DE] 09/26/2021 - Trey Flowers is downgraded to OUT Sunday vs Baltimore ( Knee ) |
| [OLB] 09/26/2021 - Julian Okwara is probable Sunday vs Baltimore ( Neck ) |
| [RB] 09/26/2021 - D'Andre Swift is probable Sunday vs Baltimore ( Groin ) |
| [OLB] 09/26/2021 - Romeo Okwara is probable Sunday vs Baltimore ( Shoulder ) |
| [DE] 09/26/2021 - Michael Brockers is probable Sunday vs Baltimore ( Shoulder ) |
| [WR] 09/26/2021 - Kalif Raymond is probable Sunday vs Baltimore ( Thigh ) |
| [DT] 09/25/2021 - Kevin Strong Jr. is OUT Sunday vs Baltimore ( Concussion ) |
| [LB] 09/23/2021 - Jamie Collins Sr. is out indefinitely ( Possible Trade ) |
| [K] 09/23/2021 - Austin Seibert is out indefinitely ( COVID-19 ) |
| [WR] 09/23/2021 - Tyrell Williams IR ( Concussion ) |
| [DB] 09/22/2021 - Ifeatu Melifonwu IR ( Leg ) |
| [CB] 09/13/2021 - Jeffrey Okudah IR, is out for season ( Achilles ) |
| [T] 09/11/2021 - Taylor Decker IR ( Finger ) |
| [DL] 09/06/2021 - Da'Shawn Hand IR ( Groin ) |
| [QB] 09/06/2021 - Tim Boyle IR ( Thumb ) |
| [OL] 09/06/2021 - Tyrell Crosby IR ( Undisclosed ) |
| [LB] 09/06/2021 - Shaun Dion Hamilton IR ( Undisclosed ) |
| [DE] 09/06/2021 - Joel Heath IR ( Knee ) |
| [T] 09/06/2021 - Dan Skipper IR ( Leg ) |
