| | Statistic | FOR | OPP |
| Total Yards per Game | 411.0 | 420.0 |
| Rushing YDS per ATT | 5.0 | 4.4 |
| Passing YDS per ATT | 7.0 | 9.3 |
| Passing Comp % | 0.720 | 0.778 |
| Total YDS per Play | 6.3 | 7.0 |
| Total YDS per Point | 14.4 | 13.8 |
|
| Injury |
| [LB] 09/24/2021 - Anthony Barr is OUT Sunday vs Seattle ( Knee ) |
| [DE] 09/24/2021 - Everson Griffen is upgraded to probable Sunday vs Seattle ( Concussion ) |
| [CB] 09/24/2021 - Harrison Hand is OUT Sunday vs Seattle ( Hamstring ) |
| [T] 09/24/2021 - Christian Darrisaw is OUT Sunday vs Seattle ( Groin ) |
| (!)[RB] 09/23/2021 - Dalvin Cook is "?" Sunday vs Seattle ( Ankle ) |
| [TE] 09/06/2021 - Irv Smith Jr. IR ( Knee ) |
| [RB] 09/06/2021 - Kene Nwangwu IR ( Knee ) |
| [WR] 09/06/2021 - Dan Chisena IR ( Undisclosed ) |
| [QB] 09/06/2021 - Nate Stanley IR ( Undisclosed ) |
| [S] 09/06/2021 - Luther Kirk IR ( Hamstring ) |
| [WR] 09/06/2021 - Blake Proehl IR ( Knee ) |
| [DE] 09/06/2021 - Janarius Robinson IR ( Undisclosed ) |
| [DT] 09/06/2021 - Jordon Scott IR ( Undisclosed ) |
| [WR] 09/06/2021 - Olabisi Johnson IR ( Knee ) |
| [WR] 09/06/2021 - Chad Beebe IR ( Foot ) |
