| | Statistic | FOR | OPP |
| Total Yards per Game | 276.0 | 333.0 |
| Rushing YDS per ATT | 3.0 | 4.8 |
| Passing YDS per ATT | 6.7 | 6.8 |
| Passing Comp % | 0.677 | 0.719 |
| Total YDS per Play | 5.1 | 5.8 |
| Total YDS per Point | 14.5 | 12.1 |
|
| Injury |
| [TE] 09/25/2021 - Dominique Dafney IR ( Hip ) |
| [G] 09/25/2021 - Elgton Jenkins is OUT Sunday vs San Francisco ( Ankle ) |
| [TE] 09/24/2021 - Josiah Deguara is probable Sunday vs San Francisco ( Concussion ) |
| [S] 09/24/2021 - Vernon Scott is probable Sunday vs San Francisco ( Hamstring ) |
| [LB] 09/17/2021 - Za'Darius Smith IR ( Back ) |
| [LB] 09/06/2021 - Randy Ramsey IR ( Ankle ) |
| [S] 09/06/2021 - Will Redmond IR ( Toe ) |
| [WR] 08/25/2021 - Devin Funchess IR ( Undisclosed ) |
| [T] 08/01/2021 - David Bakhtiari PUP ( ACL ) |
