| | Statistic | FOR | OPP |
| Total Yards per Game | 445.0 | 333.5 |
| Rushing YDS per ATT | 4.4 | 5.4 |
| Passing YDS per ATT | 9.6 | 5.9 |
| Passing Comp % | 0.735 | 0.647 |
| Total YDS per Play | 7.3 | 5.7 |
| Total YDS per Point | 12.4 | 14.5 |
|
| Injury |
| [LB] 09/26/2021 - Devon Kennard is probable Sunday vs Jacksonville ( Hamstring ) |
| [T] 09/26/2021 - Kelvin Beachum is downgraded to OUT Sunday vs Jacksonville ( Ribs ) |
| [CB] 09/26/2021 - Marco Wilson is probable Sunday vs Jacksonville ( Ankle ) |
| [WR] 09/26/2021 - DeAndre Hopkins is upgraded to probable Sunday vs Jacksonville ( Ribs ) |
| [CB] 09/26/2021 - Byron Murphy is probable Sunday vs Jacksonville ( Ankle ) |
| [OL] 09/24/2021 - Justin Pugh is probable Sunday vs Jacksonville ( Shoulder ) |
| [OL] 09/24/2021 - Brian Winters is OUT Sunday vs Jacksonville ( Personal ) |
| [OL] 09/24/2021 - Joshua Miles IR ( Ankle ) |
| [LB] 09/11/2021 - Dennis Gardeck IR ( Hand ) |
| [WR] 09/10/2021 - Antoine Wesley IR ( COVID-19 ) |
| [DE] 09/06/2021 - Jordan Phillips IR ( COVID-19 ) |
| [DT] 09/06/2021 - Jack Crawford IR ( Undisclosed ) |
| [TE] 09/06/2021 - Bruno Labelle IR ( Undisclosed ) |